Endocrine Abstracts

BACKGROUND: AGHD is associated with osteoporosis. Alterations in parathyroid gland responsiveness to changes in calcium concentration play a role in the genesis of osteoporosis.OBJECTIVES: To investigate PTH response to hypo- and hypercalcaemic stimuli in AGHD.METHODS: 12 patients with untreated AGHD were consented to the study. Venous cannulae were inserted in each arm and half-hourly blood samples collected between 0900-1800hours for PTH, calcium and albumin. After 5...

BACKGROUND: Untreated Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports suggest that bone and renal target cell insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the difference in PTH and phosphocalcium metabolism in untreated AGHD patients who have normal and reduced BMD.METHODS: 13 ...

BACKGROUND: Adult growth hormone deficiency (AGHD) is associated with osteoporosis. Growth Hormone replacement (GHR) results in increased bone mineral density (BMD), with greater benefit derived in men. PTH plays an important role in bone metabolism and reports suggest that bone and renal insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the gender difference in PTH, phosphocalcium metabolism and bone turnov...

BACKGROUND: Healthy and Adult Growth Hormone Deficient (AGHD) women exhibit elevated leptin concentrations compared with men. AGHD is characterised by obesity and associated with increased leptin concentration and decreased leptin pulsatility, however the gender variation in rhythm and pulse parameters is yet to be defined. Following growth hormone replacement (GHR), leptin concentration decreases and pulsatility increases preceding a reduction in body fat mass (BFM).<p cl...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is tightly associated with type 2 diabetes (T2DM), the principal risk factor for disease progression, liver failure and cardiovascular complications. At present there are no licensed therapies and management aims to optimise metabolic risk factors through weight loss, and pharmacological interventions for diabetes and cardiovascular disease. A multidisciplinary approa...

IntroductionMultiple myeloma is a haematological malignancy arising from plasma cells. It accounts for 10% of all haematological malignancies. Myeloma usually occurs in people over the age of 65, however, we have noted an increase occurrence of people with a younger age.Case ReportA 68 year old male, with background of hypertension and right total hip replacement, was referred to the outpatient haematology; a...

Case historyA 23-year-old female with no past medical history, presented with Acute Shortness of breath and Chest pain. CTPA revealed Bilateral Pulmonary Emboli with slightly low platelets. She was discharged on apixaban. Of note, she had received her first dose of Astra-Zeneca Covid vaccine 10 days ago. She re-presented 2days later with worsening chest pain. FBC revealed platelets 27,Hb 80,d-dimer 10,000. She was treated for presumed chest infection and...

Background and Aims: Obesity is a major risk factor for type 2 diabetes (T2D). Remission of diabetes can be achieved by dietary weight loss although the underlying molecular mechanism(s) are unknown. These beneficial effects could be related to decreasing hepatic fat delivery to the pancreas and eventually restoring β-cell function. We hypothesised that hepatic de novo lipogenesis (DNL) is the primary driver of pancreas “lipotoxicity” and the pr...

Background: For children with congenital hyperinsulinism (HI), detection and avoidance of hypoglycaemia is the cornerstone of clinical management and poses significant demands on families. Standard of care remains intermittent fingerprick monitoring but the lack of predictive information has resulted in continuous glucose monitoring (CGM) increasing in popularity. Accuracy is suboptimal in this group and family feedback identifies various barriers to use. We a...

Patients with acromegaly (PWA) experience higher rates of falls and fall-related injuries than age-matched Canadian adults. Previous studies of standing balance revealed increased sway in PWA compared to healthy controls but failed to control for the effects of the pituitary adenoma. Therefore, the aim of the present study was to determine if acromegaly influenced the neuromuscular control of standing balance. Bipedal standing balance was evaluated in PWA (n=13) in bi...